A mosaic of old and young nucleoporins.

Published in: The Journal of cell biology (2019)

Some nucleoporins, the nuclear pore complex (NPC) components, have exceptionally long lifetimes. In this issue, Toyama et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201809123) report that NPCs are maintained by a slow piecemeal replacement of NPC components in dividing and terminally differentiated cells and by whole-pore exchange in quiescent cells.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
single cell
cell death
cell therapy
signaling pathway
bone marrow
middle aged