Body composition is associated with risk of toxicity-induced modifications of treatment in women with stage I-IIIB breast cancer receiving chemotherapy.
Maaike M G A van den BergDieuwertje E KokLiesbeth PosthumaLisette KampsCeline S KelfkensNicole BuistMaud GeenenAnnebeth HaringhuizenJoan B HeijnsRianne H M A van LieshoutMaartje LosDirkje W SommeijerJohanna N H Timmer-BonteAnja Th C M de KruifHanneke W M van LaarhovenEllen KampmanRenate M WinkelsPublished in: Breast cancer research and treatment (2018)
A higher absolute and a higher relative fat mass was associated with an increased risk of toxicity-induced modifications of treatment. Absolute lean mass was not associated with risk of these treatment modifications, while higher relative lean mass associated with lower risk of modifications. These data suggest that total fat mass importantly determines the risk of toxicities during chemotherapy in breast cancer patients.