Biosafety evaluation of dual-responsive neutrobots.
Hongyue ZhangLiting WangZesheng LiYuxing JiZhiguang WuQiang HePublished in: Journal of materials chemistry. B (2022)
The toxicity effects of paclitaxel (PTX)-loaded magnetic neutrophil-hybrid swimming microrobots ("neutrobots") in vivo were assessed after intravenous administration to mice. The mice after 72 hours exhibited minimal immunotoxicity and liver and kidney toxicity at an administration dose of 3 × 10 6 PTX-loaded neutrobots. The minor toxicity of drug-loaded neutrobots holds considerable promise for biomedical applications.
Keyphrases
- cancer therapy
- drug delivery
- oxidative stress
- high fat diet induced
- wound healing
- oxide nanoparticles
- high dose
- emergency department
- machine learning
- big data
- metabolic syndrome
- wild type
- low dose
- molecularly imprinted
- insulin resistance
- adipose tissue
- artificial intelligence
- mass spectrometry
- skeletal muscle
- simultaneous determination