Tumor aggressiveness is independent of radiation quality in murine hepatocellular carcinoma and mammary tumor models.
Eshwar B UdhoShane M HuebnerDawn M AlbrechtKristina A MatkowskyjLinda ClipsonCatigan A HedicanRachel KothSantina M SnowEmily L EberhardtDevon MillerRachel Van DoornGenti GjyzeliErin K SpenglerDouglas R StortsDouglas H ThammElijah F EdmondsonMichael M WeilRichard B HalbergJeffery W BacherPublished in: International journal of radiation biology (2021)
Tumors in the HZE-irradiated mice were not more aggressive than those arising from exposure to low-LET γ-rays or spontaneously. Thus, enhanced aggressiveness does not appear to be a uniform characteristic of all tumors in HZE-irradiated animals.