Degenerate intervertebral disc-like pH induces a catabolic mechanoresponse in human nucleus pulposus cells.

Nathan W HodsonSonal PatelStephen M Richardson Judith A Hoyland Hamish T J Gilbert

Published in: JOR spine (2018)

Characterizing the influence of the mechanical and chemical intervertebral disc microenvironment on disc cells, particularly in disc degeneration, could help develop future therapeutic strategies for the treatment of discogenic back pain.

Keyphrases

induced apoptosis
cell cycle arrest
endothelial cells
stem cells
endoplasmic reticulum stress
signaling pathway
oxidative stress
pi k akt
induced pluripotent stem cells