Sinonasal Undifferentiated Carcinoma with Failed Response to Induction Chemotherapy.
Michael R PapazianAlex J GordonMichael ChowAneek PatelDonato PacioneSeth LiebermanBabak GiviPublished in: Journal of neurological surgery reports (2022)
Sinonasal undifferentiated carcinoma (SNUC) is a rapidly growing malignancy with a propensity for extensive local invasion. Multimodal therapy, including surgery, radiotherapy, and chemotherapy, is the standard approach to treatment, but the optimal sequence and combination of these modalities are uncertain. Induction chemotherapy is being increasingly utilized based on recent reports that show better outcomes for patients who respond to chemotherapy and the ability to determine further course of treatment. We present a unique case of a patient with locally advanced SNUC that did not respond to induction chemotherapy and a review of the available literature relating to the management of this rare malignancy.
Keyphrases
- locally advanced
- rectal cancer
- neoadjuvant chemotherapy
- squamous cell carcinoma
- radiation therapy
- phase ii study
- systematic review
- early stage
- type diabetes
- emergency department
- adipose tissue
- skeletal muscle
- stem cells
- radiation induced
- case report
- mesenchymal stem cells
- coronary artery disease
- lymph node
- insulin resistance
- surgical site infection
- weight loss
- percutaneous coronary intervention
- amino acid