Study on antibody Fc-glycosylation for optimal effector functions.

Vidya S ShivatarePo-Kai ChuangTzu-Hao TsengYi-Fang ZengHan-Wen HuangGannedi VeeranjaneyuluHan-Chung WuChi-Huey Wong

Published in: Chemical communications (Cambridge, England) (2023)

A comprehensive structure-activity relationship study on antibody Fc-glycosylation has been performed using the chimeric anti-SSEA4 antibody chMC813-70 as a model. The α-2,6 sialylated biantennary complex type glycan was identified as the optimal Fc-glycan with significant enhancement in antibody effector functions, including binding to different Fc receptors and ADCC.

Keyphrases

regulatory t cells
dendritic cells
structure activity relationship
stem cells
immune response