Shedding light on motor premanifest myotonic dystrophy type 1: A molecular, muscular and central nervous system follow-up study.

Joana Garmendia Garazi LabayruMiren ZulaicaJorge VillanúaAdolfo López de MunainAndone Sistiaga A

Published in: European journal of neurology (2022)

Premanifest DM1 individuals showed subtle neuroradiological alterations, which suggests CNS involvement early in the disease. Based on follow-up data, a debate emerges around the existence of a 'non-muscular DM1' subtype and/or a premanifest phase, as a precursory stage to other DM1 manifestations.

Keyphrases

resistance training
glycemic control
electronic health record
early onset
blood brain barrier
big data
cerebrospinal fluid
muscular dystrophy
adipose tissue
single molecule
high intensity