The overall results show that acute TBI is susceptible to metabolic disorders, and the joint metabolite-protein network analysis provides a favorable prediction of TBI pathogenesis mechanisms in the brain. The signatures in the hippocampus might be promising for the development of biomarkers and pathways relevant to acute TBI and could further guide testable predictions of the underlying mechanism of TBI.
Keyphrases
- traumatic brain injury
- network analysis
- liver failure
- severe traumatic brain injury
- respiratory failure
- cerebral ischemia
- aortic dissection
- drug induced
- mass spectrometry
- cognitive impairment
- subarachnoid hemorrhage
- multiple sclerosis
- prefrontal cortex
- resting state
- protein protein
- intensive care unit
- gene expression
- binding protein
- blood brain barrier