Oxidative carbonylation of N -protected indoles by Rh(III)-zeolites.
Sam Van MinnebruggenCarlos MarquezBesir KrasniqiKwinten JanssensNiels Van VelthovenJannick VercammenBenoit De SoeteAram BugaevDirk E De VosPublished in: Chemical communications (Cambridge, England) (2023)
The oxidative carbonylation of N -protected indoles was investigated to directly synthesize indole-3-carboxylic acids. Using Rh(III)-zeolites as heterogeneous catalysts, the single-site Rh-species reach unprecedented activities (>100 turnovers), while the metal is readily recovered after reaction. X-ray absorption spectroscopy (XAS) provided evidence for site-isolation of Rh(III) species on the zeolite.