Whole-genome sequencing rule-out of suspected hospital-onset Rhizopus outbreaks.
Victoria T ChuSaba NafeesEric WaltariNicole McNeilCarolyn CaughellEstella Sanchez-GuerreroLusha WangKim StanleyGail CunninghamJoan WongMaíra PhelpsCristina M TatoSteve MillerJoseph L DeRisiDeborah S YokoeLynn Ramirez-AvilaCharles R LangelierPublished in: Infection control and hospital epidemiology (2023)
Two independent temporal-spatial clusters of hospital-onset Rhizopus infections were evaluated using whole-genome sequencing (WGS). Phylogenetic analysis confirmed that isolates within each cluster were unrelated despite epidemiological suspicion of outbreaks. The ITS1 region alone was insufficient for accurate analysis. WGS has utility for rapid rule-out of suspected nosocomial Rhizopus outbreaks.