Midgut barriers prevent the replication and dissemination of the yellow fever vaccine in Aedes aegypti.
Lucie DanetGuillaume BeauclairMichèle BerthetGonzalo MoratorioSégolène GraciasFrédéric TangyValérie ChoumetNolwenn JouvenetPublished in: PLoS neglected tropical diseases (2019)
The two barriers associated with Ae. aegypti midgut prevent YFV-17D replication. Our study contributes to our basic understanding of vector-pathogen interactions and may also aid in the development of non-transmissible live virus vaccines.