Plasma and soft tissue pharmacokinetics of ceftolozane/tazobactam in healthy volunteers after single and multiple intravenous infusion: a microdialysis study.
Valentin Al JalaliM Wölfl-DuchekMax TaubertPeter MatznellerE LacknerC DornA KratzerB WulkersdorferZ ÖsterreicherM ZeitlingerPublished in: The Journal of antimicrobial chemotherapy (2021)
Tazobactam %T>CT values were distinctly below proposed target values, indicating that tazobactam might be underdosed in the investigated drug combination. However, ISF/unbound plasma ratios of ceftolozane and tazobactam support their use in soft tissue infections. A plasma and soft tissue PK model adds important information on the PK profile of ceftolozane/tazobactam. Further investigations in patients suffering from wound infections are needed to confirm these findings.
Keyphrases
- gram negative
- soft tissue
- multidrug resistant
- end stage renal disease
- ejection fraction
- newly diagnosed
- computed tomography
- low dose
- high dose
- prognostic factors
- magnetic resonance imaging
- contrast enhanced
- patient reported outcomes
- dual energy
- magnetic resonance
- image quality
- atomic force microscopy
- patient reported
- electronic health record