A Roadmap to Heart Regeneration Through Conserved Mechanisms in Zebrafish and Mammals.
Kyla D BrezitskiAlexander W GoffPaige DeBenedittisRavi KarraPublished in: Current cardiology reports (2021)
Based on studies in zebrafish and neonatal mice, cardiomyocyte proliferation has emerged as a primary strategy for effecting regeneration in the adult mammalian heart. Recent work has revealed pathways for stimulating cardiomyocyte cell cycle reentry; potential developmental barriers for cardiomyocyte proliferation; and the critical role of additional cell types to support heart regeneration. Studies in zebrafish and neonatal mice have established a template for heart regeneration. Continued comparative work has the potential to inform the translation of regenerative biology into therapeutics.
Keyphrases
- stem cells
- cell cycle
- heart failure
- cell therapy
- atrial fibrillation
- angiotensin ii
- single cell
- signaling pathway
- high fat diet induced
- mesenchymal stem cells
- wound healing
- case control
- metabolic syndrome
- adipose tissue
- bone marrow
- human health
- risk assessment
- insulin resistance
- wild type
- skeletal muscle
- tissue engineering
- solid phase extraction