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A Roadmap to Heart Regeneration Through Conserved Mechanisms in Zebrafish and Mammals.

Kyla D BrezitskiAlexander W GoffPaige DeBenedittisRavi Karra
Published in: Current cardiology reports (2021)
Based on studies in zebrafish and neonatal mice, cardiomyocyte proliferation has emerged as a primary strategy for effecting regeneration in the adult mammalian heart. Recent work has revealed pathways for stimulating cardiomyocyte cell cycle reentry; potential developmental barriers for cardiomyocyte proliferation; and the critical role of additional cell types to support heart regeneration. Studies in zebrafish and neonatal mice have established a template for heart regeneration. Continued comparative work has the potential to inform the translation of regenerative biology into therapeutics.
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