Optimising primary molecular profiling in non-small cell lung cancer.
Robert D SchoutenI SchoutenMilou M F SchuurbiersVincent van den NoortR A M DamhuisErik H F M van der HeijdenSjaak A BurgersN P BarloA S R van LindertK W MaasJ J G van den BrandA A J SmitJ M W van HaarstB van der MaatEd M D SchuuringH BlaauwgeersS M WillemsK MonkhorstD van den BroekMichel van den HeuvelPublished in: PloS one (2024)
This study shows a high success rate of tissue-based molecular profiling that was significantly improved by a protocolised approach. Tissue-based profiling remains unfeasible for a substantial proportion of patients. Combined analysis of tumour tissue and circulating tumour DNA is a promising approach to allow adequate molecular profiling of more patients.