CNA Profiling of Single CTCs in Locally Advanced Esophageal Cancer Patients during Therapy Highlights Unexplored Molecular Pathways.
Giulia GalleraniTania RossiMartina ValgiustiDavide AngeliPietro FiciSara De FantiErika BandiniClaudia CocchiGiovanni Luca FrassinetiMassimiliano BonafèFrancesco FabbriPublished in: Cancers (2021)
Our data add clues to the comprehension of the role of CTCs in EC aggressiveness: chromosomal aberrations on genes related to innate immune system behave as relevant to the onset of CTC-status, whilst pathways of transcription/gene regulation, post-transcriptional and epigenetic modifications seem linked to patients' outcome.
Keyphrases
- circulating tumor cells
- end stage renal disease
- locally advanced
- immune response
- gene expression
- transcription factor
- ejection fraction
- squamous cell carcinoma
- newly diagnosed
- copy number
- dna methylation
- chronic kidney disease
- neoadjuvant chemotherapy
- peritoneal dialysis
- genome wide
- prognostic factors
- rectal cancer
- stem cells
- single cell
- clinical trial
- lymph node
- big data
- phase ii study
- cell therapy
- open label
- smoking cessation
- genome wide identification
- double blind