Associations between locus coeruleus integrity and nocturnal awakenings in the context of Alzheimer's disease plasma biomarkers: a 7T MRI study.
Maxime Van EgrooRoy W E van HoorenHeidi I L JacobsPublished in: Alzheimer's research & therapy (2021)
Our findings provide in vivo evidence that worse LC structural integrity is associated with more frequent nocturnal awakenings in the context of neurodegeneration, in cognitively unimpaired older individuals. These results support the critical role of the LC for sleep-wake regulation in the preclinical stages of AD and hold promises for the identification of at-risk populations for preventive interventions.
Keyphrases
- physical activity
- sleep quality
- blood pressure
- obstructive sleep apnea
- cognitive decline
- simultaneous determination
- magnetic resonance imaging
- sleep apnea
- mass spectrometry
- stem cells
- cell therapy
- liquid chromatography
- depressive symptoms
- mesenchymal stem cells
- community dwelling
- computed tomography
- magnetic resonance
- diffusion weighted imaging
- high resolution