JAK1/2 Inhibitors AZD1480 and CYT387 Inhibit Canine B-Cell Lymphoma Growth by Increasing Apoptosis and Disrupting Cell Proliferation.

Z LuC C HongP C JarkA L F V AssumpçãoN BolligG KongXuan Pan

Published in: Journal of veterinary internal medicine (2017)

AZD1480 and CYT387 inhibit canine lymphoma cell growth in a dose-dependent manner. Our findings justify further phase I/II clinical investigations of the safety and efficacy of JAK1/2 inhibitors in canine DLBCL and suggest new opportunities for novel anticancer therapies.

Keyphrases

diffuse large b cell lymphoma
cell proliferation
oxidative stress
endoplasmic reticulum stress
cell cycle
signaling pathway