Role Of The C-C Motif Chemokine Ligand 5 (CCL5) And Its Receptor, C-C Motif Chemokine Receptor 5 (CCR5) In The Genesis Of Aldosterone-induced Hypertension, Vascular Dysfunction, And End-organ Damage.
Rafael M CostaDébora M CerqueiraAriane Bruder-NascimentoJuliano V AlvesWanessa Mayumi Carvalho AwataShubhnita SinghAlexander KufnerEugenia Cifuentes-PaganoPatrick J PaganoJacqueline HoThiago Bruder-NascimentoPublished in: bioRxiv : the preprint server for biology (2023)
Our data demonstrate that CCL5/CCR5, through activation of NFkB and Nox1, is critically involved in aldosterone-induced vascular and renal damage and hypertension. Our data place CCL5 and CCR5 as potential targets for therapeutic interventions in conditions with aldosterone excess.