Local patterns of genetic sharing challenge the boundaries between neuropsychiatric and insulin resistance-related conditions.
Giuseppe FanelliBarbara FrankeChiara FabbriJosefin WermeIzel ErdoganWard De WitteGeert PoelmansI Hyun RuischLianne Maria ReusVeerle van GilsWillemijn J JansenStephanie J B VosKazi Asraful AlamAurora MartinezJan HaavikTheresa WimberleySøren DalsgaardÁbel FóthiCsaba BartaFernando Fernandez-ArandaSusana Jiménez MurciaSimone BerkelSilke MaturaJordi Salas SalvadóMartina ArenellaAlessandro SerrettiNina Roth MotaJanita BraltenPublished in: medRxiv : the preprint server for health sciences (2024)
Local genetic correlations found even in the absence of global correlations.Both positive and negative local correlations found for IR-neuropsychiatric pairs.Enrichment for immune, and insulin signalling pathways, among others.Pinpointed shared likely causal variants within 10 genomic regions.Identified therapeutic targets, e.g., SLC39A8 and HLA-DRB1, for drug repurposing.