The Therapeutic Effect of Human Embryonic Stem Cell-Derived Multipotent Mesenchymal Stem Cells on Chemical-Induced Cystitis in Rats.

Sang Wook Lee Chae-Min RyuJung-Hyun ShinDaeheon ChoiAram KimHwan Yeul YuJu-Young HanHye-Yeon LeeJisun LimYong Hwan KimJinbeom HeoSeungun LeeHyein JuSujin KimKi-Sung HongJi-Yeon HanMiho SongHyung-Min ChungJun Ki KimDong-Myung Shin Myung-Soo Choo

Published in: International neurourology journal (2018)

This study demonstrates for the first time the therapeutic efficacy of hESC-derived M-MSCs on KC in rats. M-MSCs restored bladder function more effectively than did BM-derived MSCs, protecting against abnormal changes including mast cell infiltration, apoptosis and fibrotic damage.

Keyphrases

mesenchymal stem cells
umbilical cord
stem cells
oxidative stress
endothelial cells
bone marrow
cell therapy
high glucose
spinal cord injury
endoplasmic reticulum stress
cell death
diabetic rats
cell proliferation
induced pluripotent stem cells