Lidocaine Nerve Block Diminishes the Effects of Therapeutic Electrical Stimulation to Enhance Nerve Regeneration in Rats.

Grace C Keane Evan B MarshDaniel A HunterLauren SchellhardtEric R WalkerMatthew D Wood

Published in: Hand (New York, N.Y.) (2022)

Extraneural application of Lido did not damage nerves. Electrical stimulation augmented nerve regeneration, but Lido diminished the ES-related improvement in nerve regeneration. Clinical studies on the effects of ES to nerve regeneration may need to consider nerve block as a variable affecting ES outcome.

Keyphrases

stem cells
peripheral nerve
spinal cord injury
wound healing
oxidative stress
drug induced