Potential metabolic resistance mechanisms to ivermectin in Anopheles gambiae: a synergist bioassay study.

Patricia NicolasCaroline KiuruMartin G WagahMartha MuturiUrs DuthalerFelix HammannMarta MaiaCarlos J Chaccour

Published in: Parasites & vectors (2021)

There is a clear pathway for development of ivermectin resistance in malaria vectors. Detoxification mechanisms mediated by cytochrome P450 enzymes are more important than xenobiotic pumps in protecting mosquitoes against ivermectin.

Keyphrases

drug administration
aedes aegypti
plasmodium falciparum
zika virus
gene therapy