PIM1 inhibitor SMI-4a attenuated concanavalin A-induced acute hepatitis through suppressing inflammatory responses.

Xinwan WuYuwei ChenMeiru JiangLong Guo

Published in: Translational gastroenterology and hepatology (2024)

In conclusion, the protective effect of SMI-4a against acute hepatitis is by reducing the inflammatory response and apoptosis. These findings suggest that SMI-4a may have therapeutic potential in the treatment of autoimmune hepatitis.

Keyphrases

inflammatory response
liver failure
oxidative stress
drug induced
multiple sclerosis
endoplasmic reticulum stress
cell death
cell cycle arrest
cell proliferation
intensive care unit
replacement therapy
smoking cessation