Testing the causal impact of amyloidosis on total Tau using a genetically informative sample of adult male twins.

Nathan A GillespieMichael C NealeMatthew S PanizzonRuth E McKenzieXin M TuHong XianChandra A ReynoldsMichael J LyonsRobert A RissmanJeremy A ElmanCarol FranzWilliam S Kremen

Published in: bioRxiv : the preprint server for biology (2024)

Plasma Aβ40 or Aβ42 do not appear to have a direct causal impact on t-Tau. In contrast, Aβ aggregation may causally impact NFL in cognitively unimpaired men in their late 60s.

Keyphrases

cerebrospinal fluid
magnetic resonance
cognitive decline
magnetic resonance imaging
mild cognitive impairment
multiple myeloma
middle aged
contrast enhanced