African KhoeSan ancestry linked to high-risk prostate cancer.
Desiree C PetersenWeerachai JaratlerdsiriAbraham van WykEva K F ChanPedro FernandezRuth J LyonsShingai B A MutambirwAndre van der MerwePhilip A VenterWilliam BatesM S Riana BornmanVanessa M HayesPublished in: BMC medical genomics (2019)
Our study suggests that ancient KhoeSan ancestry may be linked to common modern diseases, specifically those of late onset and therefore unlikely to have undergone exclusive selective pressure. As such we show within a uniquely admixed South African population a link between KhoeSan ancestry and high-risk prostate cancer, which may explain the 2-fold increase in presentation in Black South Africans compared with African Americans.