FoxO1 as the critical target of puerarin to inhibit osteoclastogenesis and bone resorption.

Published in: The Journal of pharmacy and pharmacology (2024)

Puerarin improved the OPG/RANKL ratio, upregulated the protein expression and transcriptional activity of FoxO1, and suppressed the differentiation of RAW264.7 cells into osteoclasts. FoxO1 is a pivotal target of puerarin to confer anti-osteoporosis effects.

Keyphrases

bone loss
transcription factor
pi k akt
signaling pathway
cell cycle arrest
induced apoptosis
bone mineral density
gene expression
cell proliferation
oxidative stress
nuclear factor
soft tissue