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FoxO1 as the critical target of puerarin to inhibit osteoclastogenesis and bone resorption.

Yanling FengXulei Tang
Published in: The Journal of pharmacy and pharmacology (2024)
Puerarin improved the OPG/RANKL ratio, upregulated the protein expression and transcriptional activity of FoxO1, and suppressed the differentiation of RAW264.7 cells into osteoclasts. FoxO1 is a pivotal target of puerarin to confer anti-osteoporosis effects.
Keyphrases
  • bone loss
  • transcription factor
  • pi k akt
  • signaling pathway
  • cell cycle arrest
  • induced apoptosis
  • bone mineral density
  • gene expression
  • cell proliferation
  • oxidative stress
  • nuclear factor
  • soft tissue