A Novel Epigenetic Drug-Eluting Balloon Angioplasty Device: Evaluation in a Large Animal Model of Neointimal Hyperplasia.

HongBin LiuMelissa ByrnePatrick PerlmutterAshley WalkerGopal R SamaJegadesan SubbiahBerkay OzcelikRobert E WiddopTracey A GaspariKeith ByronYung-Chih ChenDavid M KayeAnthony E Dear

Published in: Cardiovascular drugs and therapy (2020)

Epi-Solve is a novel HDACi-coated DEBc which demonstrates significant anti-proliferative and anti-inflammatory signatures and reduced vascular endothelial cell activation compared to PABA in an ovine model and may afford endothelial protection.

Keyphrases

endothelial cells
anti inflammatory
dna methylation
gene expression
genome wide
high glucose
vascular endothelial growth factor