Assessing circulating tumour DNA (ctDNA) as a prognostic biomarker in locally advanced rectal cancer: a systematic review and meta-analysis.

Niall J O'SullivanHugo C TemperleyEimear T KyleKevin J SweeneyMaeve O'NeillCharles GilhamJacintha O'SullivanGrainne O'KaneBrian MehiganSharon O'TooleJohn LarkinDavid GallagherPaul McCormickMichael E Kelly

Published in: International journal of colorectal disease (2024)

Our systematic review provides evidence supporting the prognostic utility of ctDNA in patients with LARC, particularly in identifying patients at higher risk of disease recurrence in the post-neoadjuvant and post-operative periods.

Keyphrases

rectal cancer
locally advanced
circulating tumor
systematic review
neoadjuvant chemotherapy
phase ii study
squamous cell carcinoma
cell free
radiation therapy
circulating tumor cells
meta analyses
single molecule
lymph node
study protocol