Anesthesia blunts carbon dioxide effects on glymphatic cerebrospinal fluid dynamics in mechanically ventilated rats.

Niklas Daniel Åke PerssonTerhi J LohelaKristian Nygaard Mortensen Marko P Rosenholm Qianliang Li Pia Weikop Maiken NedergaardTuomas O Lilius

Published in: Anesthesiology (2024)

K/DEX and ISO overrode carbon dioxide as a regulator of CSF flow. K/DEX could be used to preserve CSF space and dynamics in hypercapnia whereas hyperventilation was insufficient to increase cerebral CSF perfusion under ISO.

Keyphrases

carbon dioxide
cerebrospinal fluid
intensive care unit
acute respiratory distress syndrome
subarachnoid hemorrhage
transcription factor
magnetic resonance imaging
contrast enhanced
brain injury
extracorporeal membrane oxygenation
blood brain barrier