Anesthesia blunts carbon dioxide effects on glymphatic cerebrospinal fluid dynamics in mechanically ventilated rats.
Niklas Daniel Åke PerssonTerhi J LohelaKristian Nygaard MortensenMarko P RosenholmQianliang LiPia WeikopMaiken NedergaardTuomas O LiliusPublished in: Anesthesiology (2024)
K/DEX and ISO overrode carbon dioxide as a regulator of CSF flow. K/DEX could be used to preserve CSF space and dynamics in hypercapnia whereas hyperventilation was insufficient to increase cerebral CSF perfusion under ISO.