The Combination of Daptomycin with Fosfomycin is More Effective than Daptomycin Alone in Reducing Mortality of Vancomycin-Resistant Enterococcal Bloodstream Infections: A Retrospective, Comparative Cohort Study.
Tai-Chung TsengYu-Chung ChuangJia-Ling YangChi-Ying LinSung-Hsi HuangJann-Tay WangYee-Chun ChenShan-Chwen ChangPublished in: Infectious diseases and therapy (2023)
The combination of high-dose daptomycin with fosfomycin improved the survival rate of patients with VRE-BSI compared to daptomycin alone. The benefit of the combination was most pronounced for VRE with fosfomycin MIC ≤ 64 mg/l and for patients with a low Pitt bacteremia score.