Assessment of Ketamine Adult Anesthetic Doses in Pediatrics Using Pharmacokinetic Modeling and Simulations.
Mohammed H ElkomyNabil AlruwailiMohammed ElmowafyKhaled ShalabyDavid R DroverChandra RamamoorthyPublished in: Pharmacotherapy (2019)
Weight-based dosing minimizes age-dependent variation in the plasma concentration of ketamine. Low-to-intermediate adult doses are suitable for induction and maintenance of safe anesthesia in children undergoing short-term surgical operations. However, this finding requires validation in controlled clinical trials before it is adopted into surgical standard practices.