7-T MRI tracking of mesenchymal stromal cells after lung injection in a rat model.

Stefania Maria Rita RizzoFrancesco PadelliElena RinaldiDaniela GioeniDomenico AquinoStefano BrizzolaFabio AcocellaLorenzo SpaggiariFulvio BaggiMassimo BellomiMaria Grazia BruzzoneFrancesco Petrella

Published in: European radiology experimental (2020)

Ferumoxide-labelled cells were not seen at distant sites; a linear decay of injected perfluorocarbon-labelled MSCs was observed at T0, T24, and T48 in the lung. In more than half of the experiments, perfluorocarbon-labelled MSCs scattering to the liver was observed, with a similar decay over time as observed in the lung.

Keyphrases

mesenchymal stem cells
induced apoptosis
bone marrow
lymph node
contrast enhanced
oxidative stress
computed tomography