An update to Hippocampome.org by integrating single-cell phenotypes with circuit function in vivo.
Alberto Sánchez-AguileraDiek W WheelerTeresa Jurado-ParrasManuel ValeroMiriam S NokiaElena CidIvan Fernandez-LamoNate M SuttonDaniel García-RincónLiset Menendez de la PridaGiorgio A AscoliPublished in: PLoS biology (2021)
Understanding brain operation demands linking basic behavioral traits to cell-type specific dynamics of different brain-wide subcircuits. This requires a system to classify the basic operational modes of neurons and circuits. Single-cell phenotyping of firing behavior during ongoing oscillations in vivo has provided a large body of evidence on entorhinal-hippocampal function, but data are dispersed and diverse. Here, we mined literature to search for information regarding the phase-timing dynamics of over 100 hippocampal/entorhinal neuron types defined in Hippocampome.org. We identified missing and unresolved pieces of knowledge (e.g., the preferred theta phase for a specific neuron type) and complemented the dataset with our own new data. By confronting the effect of brain state and recording methods, we highlight the equivalences and differences across conditions and offer a number of novel observations. We show how a heuristic approach based on oscillatory features of morphologically identified neurons can aid in classifying extracellular recordings of single cells and discuss future opportunities and challenges towards integrating single-cell phenotypes with circuit function.
Keyphrases
- single cell
- rna seq
- cerebral ischemia
- high throughput
- resting state
- white matter
- electronic health record
- spinal cord
- working memory
- induced apoptosis
- functional connectivity
- systematic review
- subarachnoid hemorrhage
- brain injury
- multiple sclerosis
- oxidative stress
- signaling pathway
- spinal cord injury
- gene expression
- data analysis
- dna methylation
- transcranial magnetic stimulation
- blood brain barrier
- endoplasmic reticulum stress
- current status
- artificial intelligence