Causal effects of time-varying body size on selected autoimmune disorders: a life course Mendelian randomisation study.
Dennis FreuerChrista MeisingerPublished in: RMD open (2023)
Increased birth weight appears to be a risk factor for later manifestation of rheumatoid arthritis due to both fetal genetic components and high BMI persisting into adulthood. Approaches to prevent and minimise the risk of rheumatoid arthritis could include preventing obesity in adults with high birth weight.
Keyphrases
- birth weight
- weight gain
- rheumatoid arthritis
- gestational age
- body mass index
- disease activity
- weight loss
- ankylosing spondylitis
- interstitial lung disease
- depressive symptoms
- multiple sclerosis
- type diabetes
- preterm birth
- systemic lupus erythematosus
- systemic sclerosis
- dna methylation
- idiopathic pulmonary fibrosis
- skeletal muscle