Acute hyperbilirubinemia determines an early subclinical renal damage: Evaluation of tubular biomarkers in cholemic nephropathy.

Sabrina ScillettaStefano LeggioMaurizio Di MarcoNicoletta MianoMarco MusmeciNicola Marrano Annalisa NatalicchioFrancesco GiorginoGiosiana BoscoFrancesco Di Giacomo BarbagalloAlessandra ScamporrinoStefania Di MauroAgnese FilippelloRoberto ScicaliMaurizio RusselloLuisa SpadaroFrancesco PurrelloSalvatore PiroAntonino Di Pino

Published in: Liver international : official journal of the International Association for the Study of the Liver (2024)

This study demonstrated increased urinary biomarkers of tubular damage (u-NGAL, u-B2M, u-OPN, u-TFF3, and u-Cys) in patients with mild hyperbilirubinemia in comparison with a control group. These findings suggest early renal tubular damage in the absence of alterations of the normal parameters used in clinical practice (eGFR, serum urea and renal morphology).

Keyphrases

oxidative stress
clinical practice
small cell lung cancer
liver failure
epidermal growth factor receptor
tyrosine kinase
respiratory failure
hepatitis b virus
acute respiratory distress syndrome
endothelial cells
extracorporeal membrane oxygenation