Toxic hepatitis-associated aplastic anaemia after dual homeopathic remedies and Gymnema sylvestre use.
Cyriac Abby PhilipsArif Hussain TheruvathResmi RavindranPublished in: BMJ case reports (2022)
Hepatitis-associated aplastic anaemia (HAAA) is a rare condition characterised by onset of acute hepatitis which is followed by development of severe pancytopenia due to bone marrow failure within 6 months. This syndrome can be precipitated by acute viral infections, but the aetiology remains unknown in the majority. Drug-induced HAAA is extremely rare and has been reported with nutritional and dietary supplements in current literature. We report the first cases of ayurvedic herbal and homeopathic remedies-associated HAAA in two patients which proved fatal in both. Evaluation of patients with acute hepatitis and severe pancytopenia must include a detailed evaluation for complementary and alternative medicine use.
Keyphrases
- drug induced
- liver injury
- bone marrow
- end stage renal disease
- liver failure
- ejection fraction
- chronic kidney disease
- systematic review
- allogeneic hematopoietic stem cell transplantation
- newly diagnosed
- mesenchymal stem cells
- respiratory failure
- prognostic factors
- early onset
- sars cov
- peritoneal dialysis
- intensive care unit
- acute myeloid leukemia
- iron deficiency
- electronic health record