Human intestinal organoid-derived PDGFRα + mesenchymal stroma enables proliferation and maintenance of LGR4 + epithelial stem cells.

JunLong ChenShinichiro HoriuchiSo KuramochiTomoyuki KawasakiHayato KawasumiSaeko AkiyamaTomoki AraiKenichi MorinagaTohru KimuraTohru KiyonoHidenori AkutsuSeiichi IshidaAkihiro Umezawa

Published in: Stem cell research & therapy (2024)

The high proliferative expansion, productivity, and functionality of hPSC-derived intestinal epithelial cells may have potential applications in pharmacokinetic and toxicity studies and regenerative medicine.

Keyphrases

stem cells
endothelial cells
bone marrow
climate change
signaling pathway
induced pluripotent stem cells
cell therapy
human health
mesenchymal stem cells