Tyrphostin AG490 reduces inflammation and fibrosis in neonatal obstructive nephropathy.

Mojca GasparitschAlexandra SchieberTeresa SchaubeckUrsula KellerMarco CattaruzzaBaerbel Lange-Sperandio

Published in: PloS one (2019)

Our findings provide evidence that JAK2/STAT3 mediates inflammation and fibrosis in the developing kidney with obstruction. Blocking JAK2/STAT3 may prove beneficial in congenital obstructive nephropathy in children.

Keyphrases

oxidative stress
young adults
quantum dots
liver fibrosis
highly efficient