Whole-genome sequencing of phenotypically distinct inflammatory breast cancers reveals similar genomic alterations to non-inflammatory breast cancers.

Xiaotong LiSushant KumarArif HarmanciShantao LiRobert R KitchenYan ZhangVikram B WaliSangeetha M ReddyWendy A WoodwardJames M ReubenJoel RozowskyChristos HatzisNaoto T UenoSavitri KrishnamurthyLajos PusztaiMark B Gerstein

Published in: Genome medicine (2021)

Whole-genome sequencing of IBC manifests a similar genomic architecture to non-IBC. We found no unique genomic alterations shared in just IBCs; however, subtle genomic differences were observed including germline alterations in TGFβ pathway genes and somatic mutations in the MAST2 kinase that could represent potential therapeutic targets.

Keyphrases

copy number
oxidative stress
genome wide
gene expression
dna methylation
transforming growth factor
protein kinase
climate change
epithelial mesenchymal transition