Circulating follicular helper T cells are increased in systemic sclerosis and promote plasmablast differentiation through the IL-21 pathway which can be inhibited by ruxolitinib.

Laure RicardVincent JachietFlorent MalardYishan YeNicolas StockerSébastien RivièrePatricia SenetJean-Benoit MonfortOlivier FainMohamad MohtyBéatrice GauglerArsenne Mekinian

Published in: Annals of the rheumatic diseases (2019)

Circulating Tfh cells are increased in SSc and correlate with SSc severity. The IL-21 pathway or JAK1/2 blockade by ruxolitinib could be a promising strategy in the treatment of SSc.

Keyphrases

systemic sclerosis
interstitial lung disease
induced apoptosis
regulatory t cells
dendritic cells
signaling pathway
endoplasmic reticulum stress
oxidative stress
idiopathic pulmonary fibrosis