A possible interaction between favipiravir and methotrexate: Drug-induced hepatotoxicity in a patient with osteosarcoma.

Emre DemirOsman SütçüoğluBeril DemirOktay ÜnsalOzan Yazıcı

Published in: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners (2021)

Favipiravir may inhibit methotrexate elimination by inhibiting aldehyde oxidase and its sequential use may cause hepatotoxicity in this case. The clinicians should keep in mind possible drug interactions while using new antiviral agents against SARS-CoV2 like favipiravir.

Keyphrases

drug induced
liver injury
sars cov
high dose
signaling pathway
case report
respiratory syndrome coronavirus
coronavirus disease