Integrative molecular analyses of the MD Anderson prostate cancer patient-derived xenograft (MDA PCa PDX) series.
Nicolás AnselminoEstefanía LabancaPeter D A ShepherdJiabin DongJun YangXiaofei SongSubhiksha NandakumarRitika KundraCindy J LeeNikolaus SchultzJianhua ZhangJohn C AraujoAna M AparicioSumit K SubudhiPaul Gettys CornLouis L PistersJohn F WardJohn W DavisElba S VazquezGeraldine GueronChristopher L LogothetisP Andrew FutrealPatricia TroncosoJuliet ChenNora M NavonePublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
We addressed the gap in clinically relevant PCa models through comprehensive molecular characterization of MDA PCa PDXs, providing a discovery platform that integrates with patient data and benchmarked to therapeutically relevant consensus clinical groupings. This unique resource supports robust hypothesis generation and testing from basic, translational, and clinical perspectives.