Sex differences in obesity-induced renal lipid accumulation revealed by lipidomics: a role of adiponectin/AMPK axis.

Florian JuszczakLouise PierreMorgane DecarnoncleInès JadotBlanche MartinOlivia BottonNathalie CaronJonas DehairsJohannes V SwinnenAnne-Emilie Declèves

Published in: Biology of sex differences (2023)

Collectively, our findings suggest that female mice are protected from obesity-induced renal dysfunction and lipotoxicity associated with enhanced adiponectin and AMPK signaling compared to males.

Keyphrases

insulin resistance
metabolic syndrome
high fat diet induced
high glucose
skeletal muscle
weight loss
diabetic rats
type diabetes
weight gain
oxidative stress
drug induced
adipose tissue