Recurrent secondary genomic alterations in desmoplastic small round cell tumors.

Warren A ChowJiing-Kuan YeeWalter TsarkXiwei WuHanjun QinMin GuanJeffrey S RossSiraj M AliSherri Z Millis

Published in: BMC medical genetics (2020)

In summary, recurrent secondary somatic alterations in FGFR4, ARID1A, TP53, MSH3, and MLL3 were detected in 82% of DSRCT, which is significantly greater than previously reported. These alterations may have both prognostic and therapeutic implications.

Keyphrases

copy number
single cell
acute myeloid leukemia
cell therapy
stem cells
gene expression
mesenchymal stem cells
bone marrow