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C-H Alkylation of Cubanes via Catalytic Generation of Cubyl Radicals.

Masaki HosakaShota NagasawaYoshiharu Iwabuchi
Published in: Organic letters (2024)
A catalytic method for the C-H alkylation of cubanes is described. Some hydrogen atom transfer catalysts enable the direct abstraction of a hydrogen atom from the C-H bond of cubanes, followed by conjugate addition of the generated cubyl radicals to electron-deficient alkenes. Synthetic applications of the functionalization method developed are also described.
Keyphrases
  • electron transfer
  • molecular dynamics
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