Insulin therapy for hyperglycemia in neonatal sepsis using a preterm mouse model.
Harunori MiyauchiKazumichi FujiokaSaki OkuboKosuke NishidaMariko AshinaToshihiko IkutaYuichi OkataKosaku MaedaKazumoto IijimaYuko BitohPublished in: Pediatrics international : official journal of the Japan Pediatric Society (2021)
Marked hyperglycemia was induced immediately after post-sepsis induction, and the high-dose insulin treatment increased mortality post-induction. Stress-induced hyperglycemia could therefore be a physiological and protective response for preterm sepsis, and aggressive treatment of this hyperglycemia might be contraindicated.
Keyphrases
- stress induced
- diabetic rats
- high dose
- intensive care unit
- type diabetes
- acute kidney injury
- mouse model
- septic shock
- low birth weight
- oxidative stress
- low dose
- preterm birth
- glycemic control
- high glucose
- coronary artery disease
- metabolic syndrome
- cardiovascular events
- gestational age
- adipose tissue
- endothelial cells
- combination therapy
- risk factors
- preterm infants
- weight loss