Determining the association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and genomic DNA methylation level: A meta-analysis.

Li WangShaofang ShangguanShaoyan ChangXin YuZhen WangXiaolin LuLihua WuTing Zhang

Published in: Birth defects research. Part A, Clinical and molecular teratology (2016)

The results of our study provide evidence to assess the global methylation modification alterations of MTHFR polymorphisms among individuals. However, our data did not found any conceivable proof supporting the hypothesis that common variant of MTHFR A1298C, C677T contributes to methylation modification. Birth Defects Research (Part A) 106:667-674, 2016. © 2016 Wiley Periodicals, Inc.

Keyphrases

dna methylation
genome wide
gene expression
copy number
electronic health record
gestational age
big data
data analysis
preterm birth
artificial intelligence