STING mediates microglial pyroptosis via interaction with NLRP3 in cerebral ischaemic stroke.

Wenyu LiNan ShenLingqi KongHongmei HuangXinyue WangYan ZhangGuoping WangPengfei XuWei Hu

Published in: Stroke and vascular neurology (2023)

The current findings indicate that STING modulates NLRP3-mediated microglial pyroptosis following MCAO. STING may serve as a therapeutic target in neuroinflammation induced by cerebral ischaemic/reperfusion (I/R) injury.

Keyphrases

nlrp inflammasome
cerebral ischemia
lipopolysaccharide induced
lps induced
subarachnoid hemorrhage
inflammatory response
brain injury
neuropathic pain
blood brain barrier
traumatic brain injury
acute myocardial infarction
cerebral blood flow
spinal cord injury