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CAR-Tregs as a Strategy for Inducing Graft Tolerance.

Johanna C WagnerQizhi Tang
Published in: Current transplantation reports (2020)
Donor HLA molecules are attractive candidate antigens to target with CAR Tregs in transplantation due to mismatched HLA only expressed on the transplanted organ. The feasibility of this approach has been demonstrated by several independent groups in recent years. However, substantial challenges in CAR design and preclinical modeling must be more extensively addressed prior to clinical application.
Keyphrases
  • cell therapy
  • dendritic cells
  • stem cells
  • mesenchymal stem cells
  • bone marrow